The Luiss University campus, situated between Viale Romania and Via Panama, is part of a much larger estate that belonged to Count de Heritz. In the latter half of the 19th century (1878), he consolidated several suburban villas—including Villa Digne, Villa Lecce, and Villa Simonetti—into a single property.

In 1919, when ownership passed to Società Generale Immobiliare, the entire neighborhood—Via Panama, Via Lima, and Via Lisbona—began to be developed and subdivided.

The park, which covered 2.7 hectares, was partially preserved thanks to the quality of its trees. However, Villino Digne was demolished, and in 1929, the current “neo-Baroque” style villa was built according to a design by architect Giovanni Battista Milani.

The composition is dominated by a system comprising a pronaos, a vestibule, and an elliptical grand staircase, with clear references to the Baroque style.

In 1940, the Sisters of the Assumption purchased the Villa de Heritz manor house and its adjoining park. However, it was only between 1948 and 1950 that the complex—comprising the church, the convent with its cloister, and the educational institution—was built.

Following a major restoration that preserved the buildings and park while making them functional, the site has been hosting departmental teaching and research activities, events, and seminars since 2007.